| AK | Acceptable Knowledge |
| ANL-E | Argonne National Laboratory - East (Analytical Laboratory) |
| BLM | Bureau of Land Management |
| C of C | Certificate of Compliance |
| CAST | Colorado All State Transportation, Inc. |
| CBFO | Carlsbad Field Office (DOE) |
| CCA | Compliance Certification Application |
| CCP | Central Characterization Project |
| CH-TRU | Contact-Handled Transuranic (waste) |
| CMR | Central Monitoring Room |
| CTAC | Carlsbad Field Office Technical Assistance Contractor |
| DOE | United States Department of Energy |
| DOE-CBFO | DOE Carlsbad Field Office |
| DOE-EM | DOE Office of Environmental Management |
| DOE-HQ | DOE Headquarters (also HQ) |
| EEG | Environmental Evaluation Group |
| EOC | Emergency Operations Center |
| EPA | United States Environmental Protection Agency |
| FSM | Facility Shift Manager |
| GET | General Employee Training |
| HalfPACT | NRC-certified packaging, capable of transporting seven 55-gallon drums or one standard waste box |
| Hazmat | Hazardous materials |
| HEPA | High-Efficiency Particulate Air (filter) |
| HQ | Headquarters (DOE) (also DOE-HQ) |
| ICV | Inner Containment Vessel |
| IG | Office of the Inspector General |
| INL | Idaho National Laboratory |
| ISO | International Standards Organization |
| JIC | Joint Information Center |
| LANL | Los Alamos National Laboratory |
| LLNL | Lawrence Livermore National Laboratory (Livermore, California) |
| LWA | Land Withdrawal Act (PL 102-579) |
| M&O | Management and Operating (contractor) |
| MOU | Memorandum of Understanding |
| MSDS | Material Data Safety Sheet |
| MSHA | Mine Safety and Health Administration (and Act) |
| NAS | National Academy of Sciences |
| NCI | Information Systems, Inc., the information technology contractor at WIPP |
| NDA | Nondestructive assay |
| NDE | Nondestructive examination |
| NEPA | National Environmental Policy Act |
| NMED | New Mexico Environment Department |
| NRC | Nuclear Regulatory Commission |
| NTP | National TRU Program |
| NTS | Nevada Test Site |
| OCA | Outer containment assembly |
| ORNL | Oak Ridge National Laboratory |
| PA | Performance Assessment |
| PAAA | Price-Anderson Amendments Act |
| PCB | Polychlorinated biphenyls |
| PPE | Personal protective equipment |
| QA | Quality Assurance |
| R&D | Research and development |
| RCRA | Resource Conservation and Recovery Act |
| RFP | Request for Proposal |
| SARP | Safety Analysis Report for Packaging |
| SNL | Sandia National Laboratories |
| SNL-CA | Sandia National Laboratories/California |
| SQS | Small quantity site |
| SRS | Savannah River Site |
| STEP | States and Tribal Education Program |
| SWB | Standard waste box |
| TDOP | Ten-drum overpack |
| TRANSCOM | Transportation Tracking and Communications (system) |
| TRU | Transuranic (waste) |
| TRUDOCK | TRUPACT-II Unloading Dock |
| TRUPACT | Transuranic Package TRansporter (TRU waste shipping container) |
| TRUPACT-II | Transuranic Package Transporter Model II |
| UG | Underground |
| VE | Visual examination |
| VOC | Volatile organic compound |
| WAC | Waste Acceptance Criteria |
| WAP | Waste Analysis Plan |
| WH | Waste handling |
| WHB | Waste Handling Building |
| WIPP | Waste Isolation Pilot Plant |
| WIPPTRAX | WIPP Transportation Accident Exercise (New Mexico) |
| WIPPTREX | WIPP Transportation Exercise (program) |
| WRES | Washington Regulatory and Environmental Services |
| WTS | Washington TRU Solutions LLC |
| WWIS | WIPP Waste Information System |